Genetic Association Course
(Scientific Events)

The goal of the course was to teach the course participants both theory and application of methods for linkage analysis (parametric and nonparametric).

Emphasis in this course were on strategies for genetic mapping of complex human traits. It included theory as well as practical exercises. The exercises were carried out using a variety of computer programs (PLINK, GenABEL and R, etc.) and with pencil and paper.

TOPICS included: Association analysis of qualitative and quantitative traits; single marker and haplotype analysis; data quality control; haplotype reconstruction; tagSNP selection; controlling population admixture (genomic control, principal components analysis, etc); power and sample size estimation; permutation (estimating empirical p-values); and False discovery rate (FDR).